Water → HCID 70144708、化合物

HRID 257909ノート

反応式

HRID 257909 の反応式
[CH2:1]([OH:7])/[CH:2]=[CH:3]\[CH2:4][CH2:5][CH3:6].[H-].[Na+].Cl[C:11]1[C:12]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[N:13][S:14][N:15]=1.O>O1CCCC1>[CH2:1]([O:7][C:11]1[C:12]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[N:13][S:14][N:15]=1)/[CH:2]=[CH:3]\[CH2:4][CH2:5][CH3:6]

参加物

6

反応物 4

HCID 962WaterHCID 24758Sodium hydrideHCID 53244892-Hexen-1-ol, (2Z)-HCID 104881643-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole

生成物 1

HCID 70144708HCID 70144708、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of cis-2-hexen-1-ol (900 mg, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl) pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 1 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.

後処理

  1. extractionthe mixture was extracted with ether
  2. dry with materialThe ether phase was dried
  3. customevaporated

出典と根拠

ORDレコード
ord-b0d52508a0e5449ba4cc3859678450a5
出典データセット
uspto-grants-1993_11
特許番号
US05264444

反応ノート

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