Hydrochloric Acid → 2-Aminoterephthalic acid

HRID 258060

反応式

HRID 258060 の反応式
[NH2:1][C:2]1[CH:11]=[C:10]([C:12]([O:14]C)=[O:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].Cl>[Br-].C([N+](C)(C)C)CCCCCCCCCCCCCCC.[OH-].[Na+]>[NH2:1][C:2]1[CH:11]=[C:10]([C:12]([OH:14])=[O:13])[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 79336Dimethyl aminoterephthalate

生成物 1

HCID 27248222-Aminoterephthalic acid収率 89%

試薬・触媒・溶媒 2

HCID 5974Hexadecyltrimethylammonium Bromide触媒HCID 14798Sodium Hydroxide溶媒

実験手順

A representative preparation was done as follows: Dimethyl aminoterephthalate (5 g), cetyltrimethyl ammonium bromide catalyst (0.05 g) and aqueous NaOH solution (5%, 300 ml) were taken in a 500 ml round bottom flask, and heated to and held at about 60° C. for about 2 hours. The mixture was then cooled to about 15°-20° C., and acidified with concentrated HCl when the acid of Formula 3 separated as yellow crystals. This was filtered, washed with ice cold water, and dried (yield: 89%).

後処理

  1. customA representative preparation
  2. temperatureheated to and
  3. temperatureThe mixture was then cooled to about 15°-20° C.
  4. customseparated as yellow crystals
  5. filtrationThis was filtered
  6. washwashed with ice cold water
  7. customdried (yield: 89%)

出典と根拠

ORDレコード
ord-a8157de3536c4b3ab4ef96abe13fc8c2
出典データセット
uspto-grants-1993_11
特許番号
US05264539

関連ノート

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