Water → 2-Phenyl-4-(beta-hydroxyethyl)thiazole

HRID 258577

反応式

HRID 258577 の反応式
[C:1]1([C:7]2[S:8][CH:9]=[C:10]([CH2:12][C:13](OCC)=[O:14])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[C:1]1([C:7]2[S:8][CH:9]=[C:10]([CH2:12][CH2:13][OH:14])[N:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 962WaterHCID 2797666Ethyl 2-(2-phenyl-1,3-thiazol-4-yl)acetateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 106083152-Phenyl-4-(beta-hydroxyethyl)thiazole

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Reduction of the latter ester to the title compound is effected as follows: The ester (159 g) is dissolved in dry tetrahydrofuran (250 ml) and added dropwise during 30 min to a stirred mixture of lithium aluminum hydride (50 g) in tetrahydrofuran. The mixture is stirred for one hour, cooled and water (150 ml) is slowly added. The mixture is dried over magnesium sulfate and evaporated to give the title compound as a yellow oil, γmaxCHCl3 3610, 3420 and 1520 cm- 1.

後処理

  1. temperaturecooled
  2. dry with materialThe mixture is dried over magnesium sulfate
  3. customevaporated

出典と根拠

ORDレコード
ord-5f3d911fa4f342a987c166e3d11b4fc7
出典データセット
uspto-grants-1977_07
特許番号
US04033977

関連ノート

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