Methanol → p-Chloro-o-toluidine hydrochloride

HRID 258634

反応式

HRID 258634 の反応式
[Cl:1]Cl.C([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:12])=O.CO>C(Cl)(Cl)Cl>[ClH:1].[NH2:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:1])=[CH:8][C:7]=1[CH3:12]

参加物

5

反応物 3

HCID 887MethanolHCID 7202Formamide, N-(2-methylphenyl)-HCID 24526Chlorine

生成物 1

HCID 18487p-Chloro-o-toluidine hydrochloride収率 132.7%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

79 g (1.1 moles) of chlorine is introduced into a solution of 135 g (1 mole) of 2 -formylaminotoluene in 500 ml of chloroform at 20° to 25° C. in the course of 2 to 3 hours. After the addition of 28 g (0.88 mole) of methanol, the mixture obtained is stirred for 2 hours at 25° to 30° C., and the formed 2 -amino-5 -chlorotoluene hydrochloride is subsequently filtered off. There is obtained 130 g (73% of theory relative to 2 -formylaminotoluene) of 2 -amino-5 -chlorotoluene hydrochloride. The content of 2 -amino-5 -chlorotoluene hydrochloride in the product is 98 to 99%.

後処理

  1. customthe mixture obtained
  2. filtrationthe formed 2 -amino-5 -chlorotoluene hydrochloride is subsequently filtered off

出典と根拠

ORDレコード
ord-224e2f4cc30946509a1b5f6797145d9f
出典データセット
uspto-grants-1977_07
特許番号
US04034043

関連ノート

読み込み中…