Pyridine → 5-Isopropoxycarbonylamino-2-phenyloxazolo[5,4-b]pyridine

HRID 259556ノート

反応式

HRID 259556 の反応式
[NH2:1][C:2]1[N:7]=[C:6]2[O:8][C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:10][C:5]2=[CH:4][CH:3]=1.N1C=CC=CC=1.[CH:23]([O:26][C:27](Cl)=[O:28])([CH3:25])[CH3:24]>O>[CH:23]([O:26][C:27]([NH:1][C:2]1[N:7]=[C:6]2[O:8][C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:10][C:5]2=[CH:4][CH:3]=1)=[O:28])([CH3:25])[CH3:24]

参加物

5

反応物 3

HCID 1049PyridineHCID 7917Isopropyl chloroformateHCID 227547935-Amino-2-phenyloxazolo[5,4-b]pyridine

生成物 1

HCID 227548035-Isopropoxycarbonylamino-2-phenyloxazolo[5,4-b]pyridine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 300 mg. of 5-amino-2-phenyloxazolo[ 5,4-b]pyridine and 3 ml. of pyridine was cooled in ice and to it was added 0.2 ml. of isopropylchloroformate. The mixture was allowed to age in the refrigerator for 5 days, and diluted with ice and water. The precipitate was collected and recrystallized from isopropanol to give 5-isopropoxycarbonylamino-2-phenyloxazolo[ 5,4-b]pyridine, m.p. 210°-211° C.

後処理

  1. additionA mixture of 300 mg
  2. additionwas added 0.2 ml
  3. customThe precipitate was collected
  4. customrecrystallized from isopropanol

出典と根拠

ORDレコード
ord-08a2e0c4a7584ceda3507a0329221d89
出典データセット
uspto-grants-1977_07
特許番号
US04038396

反応ノート

読み込み中…