Sodium Hydroxide → 3-Tert-butyl-2-methoxybenzoic acid

HRID 259578

反応式

HRID 259578 の反応式
[C:1]([C:5]1[C:6]([O:12][CH3:13])=[C:7]([CH3:11])[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[Mn]([O-])(=O)(=O)=[O:15].[K+].[OH-:20].[Na+]>>[C:1]([C:5]1[C:6]([O:12][CH3:13])=[C:7]([CH:8]=[CH:9][CH:10]=1)[C:11]([OH:15])=[O:20])([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 3

HCID 14798Sodium HydroxideHCID 516875Potassium Permanganate2 回HCID 521940Benzene, 1-(1,1-dimethylethyl)-2-methoxy-3-methyl-

生成物 1

HCID 156915293-Tert-butyl-2-methoxybenzoic acid

実験手順

A mixture of 0.01 mole of 3-t-butyl-2-methoxytoluene, 0.01 mole of potassium permanganate, and 100 ml. of 1 N sodium hydroxide solution is heated to reflux and another 0.01 mole of potassium permanganate is added each hour until a total of 0.05 mole has been added (4 hours). After another 2 hours of reflux the unreacted starting material is steam distilled. Ethanol is added to the residue to decompose excess permanganate and mixture is filtered hot. Acidification with sulfuric acid of the filtrate causes precipitation of the product which is collected, washed with water and dried to give 3-t-butyl-2-methoxybenzoic acid.

後処理

  1. temperatureto reflux
  2. additionhas been added (4 hours)
  3. temperatureAfter another 2 hours of reflux the
  4. distillationdistilled
  5. additionEthanol is added to the residue
  6. filtrationis filtered hot
  7. customprecipitation of the product which
  8. customis collected
  9. washwashed with water
  10. customdried

出典と根拠

ORDレコード
ord-f452fd2f998a4f7288c30dd803c0df99
出典データセット
uspto-grants-1977_07
特許番号
US04038396

関連ノート

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