4-Chlorophenol → 1-Phenyl-1-(4'-chlorophenoxy)-3,3-dimethyl-butan-2-one

HRID 25965

反応式

HRID 25965 の反応式
Br[CH:2]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3](=[O:8])[C:4]([CH3:7])([CH3:6])[CH3:5].[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=1.[Na]>C(OCC)(=O)C.C(O)C>[C:9]1([CH:2]([O:22][C:19]2[CH:20]=[CH:21][C:16]([Cl:15])=[CH:17][CH:18]=2)[C:3](=[O:8])[C:4]([CH3:7])([CH3:6])[CH3:5])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

参加物

6

反応物 3

HCID 46844-ChlorophenolHCID 5360545SodiumHCID 134586931-Bromo-3,3-dimethyl-1-phenylbutan-2-one

生成物 1

HCID 213260281-Phenyl-1-(4'-chlorophenoxy)-3,3-dimethyl-butan-2-one収率 67%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 25.4 g (0.1 mole) of 1-bromo-1-phenyl-3,3-dimethyl-butan-2-one in 50 ml of ethyl acetate was added dropwise, at the boil, to a solution of 12.85 g (0.1 mole) of 4-chlorophenol and 2.3 g (0.1 mole) of sodium in 100 ml of ethanol. After boiling for 12 hours under reflux, the sodium bromide which had separated out was filtered off hot. The filtrate was distilled in vacuo and the solid residue which remained was recrystallized from ligroin. 20.2 g (67% of theory) of 1-phenyl-1-(4'-chlorophenoxy)-3,3-dimethyl-butan-2-one of melting point 103° C. were obtained.

後処理

  1. temperatureunder reflux
  2. customthe sodium bromide which had separated out
  3. filtrationwas filtered off hot
  4. distillationThe filtrate was distilled in vacuo
  5. customthe solid residue which remained was recrystallized from ligroin

出典と根拠

ORDレコード
ord-2a6191e666fa47fc92c5b3dc0bd416f8
出典データセット
uspto-grants-1979_04
特許番号
US04147791

関連ノート

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