4-Methoxyphenylacetaldehyde → 1-Benzhydrylamino-2-(4-methoxyphenyl)-ethanephosphonous acid

HRID 25985

反応式

HRID 25985 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]=O)=[CH:5][CH:4]=1.[Na].[PH2:13]([O-:15])=[O:14].[CH:16]([NH3+:29])([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH:16]([NH:29][CH:10]([P:13]([OH:15])[OH:14])[CH2:9][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)([C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 3

HCID 797824-MethoxyphenylacetaldehydeHCID 5360545Sodium2 回HCID 178527021HCID 178527021、化合物

生成物 1

HCID 213258811-Benzhydrylamino-2-(4-methoxyphenyl)-ethanephosphonous acid

実験手順

10 parts of freshly distilled p-methoxyphenylacetaldehyde in 20 parts of sodium-dried dioxan was added to a suspension of 17 parts of benzhydrylammonium hypophosphite in 100 parts of sodium-dried dioxan under reflux and under nitrogen as in Example 17 above. 70 Parts dioxan/water was removed. 125 Parts of alcohol was added and DL-1-benzhydrylamino-2-(4-methoxyphenyl)-ethanephosphonous acid, melting point 199°-202°, was obtained.

後処理

  1. temperatureunder reflux and under nitrogen as in Example 17 above
  2. custom70 Parts dioxan/water was removed
  3. addition125 Parts of alcohol was added

出典と根拠

ORDレコード
ord-dd34e67a365840f7bd89be9836dcf4be
出典データセット
uspto-grants-1979_04
特許番号
US04147780

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