Ammonia → 2-Amino-5-fluorobenzoic acid

HRID 259920

反応式

HRID 259920 の反応式
[Na].[F:2][C:3]1[CH:4]=[CH:5][C:6](Br)=[C:7]([CH:11]=1)[C:8]([OH:10])=[O:9].[K].[NH3:14]>[OH-].[K+]>[F:2][C:3]1[CH:11]=[C:7]([C:8]([OH:10])=[O:9])[C:6]([NH2:14])=[CH:5][CH:4]=1

参加物

6

反応物 4

HCID 222AmmoniaHCID 27781812-Bromo-5-fluorobenzoic acid2 回HCID 5360545SodiumHCID 5462222Potassium

生成物 1

HCID 1014122-Amino-5-fluorobenzoic acid

試薬・触媒・溶媒 1

HCID 14797Potassium Hydroxide溶媒

実験手順

If the sodium salt solution of 5-fluoro-2-bromobenzoic acid is replaced by aliquot parts of the potassium or ammonium salt solution, prepared by dissolving 219 parts of 5-fluoro-2-bromobenzoic acid in 256.1 parts of 21.9% strength aqueous potassium hydroxide or, respectively, 217 parts of 7.9% aqueous ammonia solution and used as the metering medium in a procedure otherwise identical to that indicated, then 5-fluoroanthranilic acid is obtained in identical yield and quality.

後処理

  1. customprepared

出典と根拠

ORDレコード
ord-4f2f20decea5457bb0487fd375f40d1a
出典データセット
uspto-grants-1996_06
特許番号
US05523472

関連ノート

読み込み中…