Water → 2-Fluoro-5-methoxybenzoic acid

HRID 259933

反応式

HRID 259933 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH3:10].[Mn]([O-])(=O)(=O)=[O:12].[K+].[OH2:17]>N1C=CC=CC=1>[F:1][C:2]1[C:3]([C:10]([OH:12])=[O:17])=[CH:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 1375464-Fluoro-3-methylanisoleHCID 516875Potassium Permanganate

生成物 1

HCID 27745432-Fluoro-5-methoxybenzoic acid

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

4-Fluoro-3-methylanisol (1.0 g, 7.1 mmol) was dissolved in a mixture of pyridine (16 mL) and water (32 mL). Potassium permanganate (3.4 g, 21 mmol) was added and the reaction mixture was refluxed for 3 h and then left at room temperature over night. After filtration and extraction with CH2Cl2 the aqueous phase was acidified with HCl precipitating the product (440 mg).

後処理

  1. temperaturethe reaction mixture was refluxed for 3 h
  2. waitleft at room temperature over night
  3. filtrationAfter filtration and extraction with CH2Cl2 the aqueous phase

出典と根拠

ORDレコード
ord-467aaa5bc85d4a349ff0c6b06ef72370
出典データセット
uspto-grants-1996_06
特許番号
US05523475

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