Methyl iodide → 2,2-Dimethylhexanenitrile
反応式
[CH3:1][C:2]([CH3:9])([CH2:5][CH2:6][CH2:7][CH3:8])[CH2:3][NH2:4].C(#N)CCCCC.CI.[NH2-].[Na+]>O.C1(C)C=CC=CC=1>[CH3:1][C:2]([CH3:9])([CH2:5][CH2:6][CH2:7][CH3:8])[C:3]#[N:4]参加物
7
実験手順
2,2-Dimethylhex-1-ylamine--A solution of capronitrile (25 g., 0.26 mole) and methyl iodide (75 g., 0.53 Mole) in 80 ml. of dry toluene is warmed to 80° and treated gradually with a suspension of sodium amide (25.4 g., 0.65 mole) in 100 ml. of toluene at a rate sufficient to maintain general reflux. After addition is complete, the mixture is stirred and refluxed for an additional 2 hr. period, cooled and treated with 150 ml. of water. The organic layer is separated, washed with water and dried over magnesium sulfate. Concentration of the dried solution under reduced pressure and distillation of residual material affords an 81% yield of 2,2-dimethylcapronitrile.
後処理
- temperaturereflux
- additionAfter addition
- temperaturerefluxed for an additional 2 hr
- temperatureperiod, cooled
- additiontreated with 150 ml
- customThe organic layer is separated
- washwashed with water
- dry with materialdried over magnesium sulfate
- distillationConcentration of the dried solution under reduced pressure and distillation of residual material
出典と根拠
- ORDレコード
- ord-5bd37b2088b54876b42705cb51901d8c
- 出典データセット
- uspto-grants-1979_04
- 特許番号
- US04147805
反応ノート
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