Dimethylformamide → 3-Methoxy-2-nitrobenzoyl chloride
反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].CN(C=O)C.[CH3:12][O:13][C:14]1[C:15]([N+:23]([O-:25])=[O:24])=C([CH:20]=[CH:21][CH:22]=1)C(O)=O>ClCCl>[CH3:12][O:13][C:14]1[C:15]([N+:23]([O-:25])=[O:24])=[C:1]([CH:20]=[CH:21][CH:22]=1)[C:2]([Cl:4])=[O:3]参加物
5
反応条件
- 温度
- 25 °C
実験手順
Oxalyl chloride (2 mL, 24 mmol) and DMF (0.4 mL) are added to a suspension of 3-methoxy-2-nitro benzoic acid (4 g, 20 mmol) in 200 mL of dichloromethane. The reaction mixture is stirred for 3 hours at 25° C. under nitrogen. The reaction solvents are removed under reduced pressure to yield 3-methoxy-2-nitrobenzoyl chloride (4.3 g, quant.) as a yellow solid. 1H NMR (DMSO): δ7.80 (1H, d, J=8 Hz), 7.65 (1H, t, J=9 Hz), 7.42 (1H, d, J=10 Hz).
後処理
- customThe reaction solvents are removed under reduced pressure
出典と根拠
- ORDレコード
- ord-68c473f454ac43e7bf0a2f8fde1a2df6
- 出典データセット
- uspto-grants-1996_06
- 特許番号
- US05525625
反応ノート
読み込み中…