Dimethylthiocarbamoyl chloride → Dimethylthiocarbamoyl valine

HRID 260133

反応式

HRID 260133 の反応式
C([O:3][C:4](=[O:10])[C@H:5]([CH:7]([CH3:9])[CH3:8])[NH2:6])C.[CH3:11][N:12]([CH3:16])[C:13](Cl)=[S:14]>C(#N)C>[CH3:11][N:12]([CH3:16])[C:13]([NH:6][C@H:5]([C:4]([OH:3])=[O:10])[CH:7]([CH3:9])[CH3:8])=[S:14]

参加物

4

反応物 2

HCID 27871Dimethylthiocarbamoyl chlorideHCID 87182l-Valine, ethyl ester

生成物 1

HCID 53885838Dimethylthiocarbamoyl valine

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Valine ethyl ester (0.0028 mol) in 10 ml acetonitrile was reacted with dimethylthiocarbamoyl chloride (0.0056 mol) at 50° C. for 2 hours. Solvent acetonitrile was removed by rotary evaporation. Trifluoroacetic acid (10 ml) was added and the mixture stirred at room temperature for 15 min. The trifluoroacetic acid was removed by rotary evaporation. The residue was dissolved in water and analyzed by FAB/MS. The expected product, dimethylthiocarbamoyl valine (MH+=205), was obtained.

後処理

  1. customSolvent acetonitrile was removed by rotary evaporation
  2. additionTrifluoroacetic acid (10 ml) was added
  3. customThe trifluoroacetic acid was removed by rotary evaporation
  4. dissolutionThe residue was dissolved in water

出典と根拠

ORDレコード
ord-7c3f4ac9582a492d88c902c8d1fa939d
出典データセット
uspto-grants-1996_06
特許番号
US05525707

関連ノート

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