Pyridine → 2-Pyrrolidinone, 3-hydroxy-1-methyl-5-(3-pyridinyl)-

HRID 260251ノート

反応式

HRID 260251 の反応式
N1C=CC=CC=1.[CH3:7][N:8]1[C:12](=[O:13])[C@H:11]([OH:14])[CH2:10][C@H:9]1[C:15]1[CH:20]=[CH:19][CH:18]=[N:17][CH:16]=1>CN(C=O)C.C1(=O)OC(=O)CC1>[CH3:7][N:8]1[C:12](=[O:13])[CH:11]([OH:14])[CH2:10][CH:9]1[C:15]1[CH:20]=[CH:19][CH:18]=[N:17][CH:16]=1

参加物

5

反応物 2

HCID 1049PyridineHCID 1079633'-Hydroxycotinine, trans-

生成物 1

HCID 4142-Pyrrolidinone, 3-hydroxy-1-methyl-5-(3-pyridinyl)-

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 7922Succinic anhydride溶媒

実験手順

Hydroxycotinine hemisuccinate was prepared as follows. In a glass tube, 19 mg of trans-3'-hydroxycotinine were dissolved in 1 ml of DMF. In this solution 21 mg of succinic anhydride were dissolved. After adding 20 μl of pyridine, the tube was covered (PARAFILM®) and incubated overnight at 37° C.

後処理

  1. custom(PARAFILM®) and incubated overnight
  2. customat 37° C.

出典と根拠

ORDレコード
ord-75f5640dafa64d76af267b510fdfec74
出典データセット
uspto-grants-1996_06
特許番号
US05527686

反応ノート

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