Thionyl Chloride → Benzoyl chloride, 3-methoxy-2-methyl-

HRID 260806ノート

反応式

HRID 260806 の反応式
[CH3:1][O:2][C:3]1[C:4]([CH3:12])=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](O)=[O:7].S(Cl)([Cl:15])=O>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[C:4]([CH3:12])=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([Cl:15])=[O:7]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 70214833-Methoxy-2-MethylBenzoic Acid

生成物 1

HCID 14719554Benzoyl chloride, 3-methoxy-2-methyl-収率 86.3%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To 3-methoxy-2-methylbenzoic acid (454 g, 2.73 moles) in 1300 mL chloroform containing 20 g dimethyl formamide at 65° C., thionyl chloride (390 g) was added dropwise over 6 hours, whereupon the solvent was removed by evaporation at a reduced pressure. The residue (512 g) was distilled at 110° C. at 1-2 mm Hg to give 3-methoxy-2-methylbenzoyl chloride (435 g).

後処理

  1. customwas removed by evaporation at a reduced pressure
  2. distillationThe residue (512 g) was distilled at 110° C. at 1-2 mm Hg

出典と根拠

ORDレコード
ord-cb926d2aa9224368b623b498e409449b
出典データセット
uspto-grants-1996_06
特許番号
US05530028

反応ノート

読み込み中…