Benzyl Alcohol → Benzyl 6-Bromohexyl Ether

HRID 260820ノート

反応式

HRID 260820 の反応式
[H-].[Na+].[CH2:3]([OH:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[Br:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]Br>O1CCOCC1>[Br:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:10][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 244Benzyl AlcoholHCID 123681,6-DibromohexaneHCID 24758Sodium hydride

生成物 1

HCID 2784764Benzyl 6-Bromohexyl Ether

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒3 回

実験手順

To a suspension of sodium hydride in 1,4-dioxane was added benzyl alcohol in 1,4-dioxane over a period of 30 minutes at 80° C., and the mixture was stirred for 1 hour. The obtained alkoxide solution was added to a solution of 1,6-dibromohexane in 1,4-dioxane at room temperature. The mixture was stirred at 80° C. for 14 hours and insoluble materials were filtered off. The filtrate was concentrated and the residue was distilled under reduced pressure to give the object compound.

後処理

  1. stirringThe mixture was stirred at 80° C. for 14 hours
  2. filtrationinsoluble materials were filtered off
  3. concentrationThe filtrate was concentrated
  4. distillationthe residue was distilled under reduced pressure
  5. customto give the object compound

出典と根拠

ORDレコード
ord-9d1d155b2a884e578db41fc4e08d3656
出典データセット
uspto-grants-1996_06
特許番号
US05530019

反応ノート

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