Water → 7-Bromo-5-methyl-3-phenylbenzofuran

HRID 262089

反応式

HRID 262089 の反応式
[Br:1][C:2]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:3]=1[O:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O.O>C(Cl)(Cl)Cl>[Br:1][C:2]1[C:3]2[O:4][CH:5]=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:14]=2[CH:15]=[C:16]([CH3:18])[CH:17]=1

参加物

4

反応物 2

HCID 962WaterHCID 40772362-(2-Bromo-4-methylphenoxy)acetophenone

生成物 1

HCID 213199287-Bromo-5-methyl-3-phenylbenzofuran

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A mixture of 700 g. of polyphosphoric acid and 100 g. of α-(2-bromo-4-methylphenoxy)acetophenone is heated at 80°-90° C. for two hours, then poured into two liters of water with stirring. Chloroform (1 liter) is added, and the phases are separated. The organic layer is washed with water, dried, then evaporated to provide 7-bromo-5-methyl-3-phenylbenzofuran as a brown oil.

後処理

  1. additionA mixture of 700 g
  2. customthe phases are separated
  3. washThe organic layer is washed with water
  4. customdried
  5. customevaporated

出典と根拠

ORDレコード
ord-8e550f305de947eaa87715bf888aacd9
出典データセット
uspto-grants-1979_05
特許番号
US04153619

関連ノート

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