Hydrochloric Acid → 4-(2-Thienyl)-4-oxobutyric acid oxime
反応式
Cl.[NH2:2][OH:3].[OH-].[Na+].[S:6]1[CH:10]=[CH:9][CH:8]=[C:7]1[C:11](=[O:17])[CH2:12][CH2:13][C:14](O)=[O:15].Cl>O>[S:6]1[CH:10]=[CH:9][CH:8]=[C:7]1[C:11](=[O:17])[CH2:12][CH2:13][C:14](=[N:2][OH:3])[OH:15]参加物
6
実験手順
A mixture of 22.6 g. of hydroxylamine hydrochloride and 26 g. of NaOH in 300 ml. of water is stirred and 30 g. of 4-(2-thienyl)-4-oxobutyric acid is added to afford a clear yellow solution. The mixture is stirred for two hours at room temperature and acidified with 3N HCl to pH 2 to give a white precipitate. After stirring an additional half hour, the mixture is cooled in ice and filtered. The filter cake is washed with water and dried to afford the title compound, m.p. 133°-138° C.
後処理
- additionA mixture of 22.6 g
- customto afford a clear yellow solution
- customto give a white precipitate
- stirringAfter stirring an additional half hour
- temperaturethe mixture is cooled in ice
- filtrationfiltered
- washThe filter cake is washed with water
- customdried
出典と根拠
- ORDレコード
- ord-0b5b7ffc77e843b4b9ffff6d8d6fc71c
- 出典データセット
- uspto-grants-1979_05
- 特許番号
- US04154740
反応ノート
読み込み中…