Nitroethane → 1-(3'-Trifluoromethoxyphenyl)-2-nitro-propene

反応式

[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH:7]=O.[N+:14]([CH2:17][CH3:18])([O-:16])=[O:15].C(N)CCC>>[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:5]=[C:6]([CH:7]=[C:17]([N+:14]([O-:16])=[O:15])[CH3:18])[CH:9]=[CH:10][CH:11]=1

参加物

反応物 3

HCID 6587Nitroethane

HCID 8007Butylamine

HCID 6051393-(Trifluoromethoxy)benzaldehyde

生成物 1

HCID 539111051-(3'-Trifluoromethoxyphenyl)-2-nitro-propene収率 70%

実験手順

32 g (0.17 mol) of 3-trifluoromethoxy-benzaldehyde, 32 ml of nitro-ethane and 2 ml of n-butylamine are introduced into a 100 ml flask surmounted by a condenser. The mixture is heated for 20 hours at the reflux temperature and then rectified. 29 g (70% yield) of 1-(3'-trifluoromethoxy-phenyl)-2-nitro-1-propene are collected as a yellow oil b.p. 90°-110° C./2mm. Hg.