Acetic Acid → HCID 14338586、化合物
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]1[C:9](=[O:15])[NH:10][C:11](=[S:14])[NH:12][CH:13]=1.CI.[OH-].[Na+].[C:20](O)(=O)C>O.C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]1[C:9](=[O:15])[NH:10][C:11]([S:14][CH3:20])=[N:12][CH:13]=1参加物
7
実験手順
A solution of 5-(2-pyridylmethyl)-2-thiouracil (6.6 g), methyl iodide (4.3 g) and sodium hydroxide (2.5 g) in water (100 ml) and ethanol (100 ml) was stirred at 70° for 30 minutes, allowed to cool and glacial acetic acid added to pH5. The solution was partially evaporated and cooled in an ice-bath. The precipitate was filtered off and recrystalled from ethanol to give 5-(2-pyridylmethyl)-2-methylthio-4-pyrimidone, m.p. 195°-197.5°.
後処理
- temperatureto cool
- customThe solution was partially evaporated
- temperaturecooled in an ice-bath
- filtrationThe precipitate was filtered off
出典と根拠
- ORDレコード
- ord-eb9363deb6c9406e96080389abd68f25
- 出典データセット
- uspto-grants-1979_05
- 特許番号
- US04154834
反応ノート
読み込み中…