Formicin → 3-Acetamidomethylthio-2-methylpropanoic acid

HRID 262582ノート

反応式

HRID 262582 の反応式
[SH:1][CH2:2][CH:3]([CH3:7])[C:4]([OH:6])=[O:5].O[CH2:9][NH:10][C:11](=[O:13])[CH3:12]>FC(F)(F)C(O)=O>[C:11]([NH:10][CH2:9][S:1][CH2:2][CH:3]([CH3:7])[C:4]([OH:6])=[O:5])(=[O:13])[CH3:12]

参加物

4

反応物 2

HCID 69365FormicinHCID 1529103-Mercaptoisobutyric acid

生成物 1

HCID 213191453-Acetamidomethylthio-2-methylpropanoic acid

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

3-Mercapto-2-methylpropanoic acid (2.4 g.) and N-hydroxymethylacetamide (1.8 g.) are dissolved in trifluoroacetic acid and the solution is stored at room temperature for one hour. The trifluoroacetic acid is removed in vacuo and the residue is dried in vacuo over potassium hydroxide to yield 3-acetamidomethylthio-2-methylpropanoic acid.

後処理

  1. customThe trifluoroacetic acid is removed in vacuo
  2. dry with materialthe residue is dried in vacuo over potassium hydroxide

出典と根拠

ORDレコード
ord-0608b8bc62914d75bd49bba4023019fe
出典データセット
uspto-grants-1979_05
特許番号
US04154840

反応ノート

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