Water → Ethyl alpha-phthalimidopentanoate

HRID 26313

反応式

HRID 26313 の反応式
[C:1]1(=[O:11])[NH:5][C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[K].[CH2:13]([O:15][C:16](=[O:22])[CH:17](Br)[CH2:18][CH2:19][CH3:20])[CH3:14].C(Cl)(Cl)Cl.O>CN(C)C=O>[C:1]1(=[O:11])[N:5]([CH:17]([CH2:18][CH2:19][CH3:20])[C:16]([O:15][CH2:13][CH3:14])=[O:22])[C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12

参加物

6

反応物 4

HCID 962WaterHCID 6212ChloroformHCID 79071Ethyl 2-bromovalerateHCID 24194345Phthalimide potassium salt

生成物 1

HCID 13791337Ethyl alpha-phthalimidopentanoate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

反応条件

温度
60 °C

実験手順

To a solution of potassium phthalimide (0.1 mole) in about 50 ml of dimethylformamide (DMF) is added 1 equivalent of ethyl-2-bromopentanoate. The temperature is maintained at about 60° C. for 10 minutes. Chloroform is added to the cooled DMF solution and the mixture is poured into water. The phases are separated and the aqueous phase is extracted with chloroform. The chloroform extracts are combined, extracted with 0.1 N sodium hydroxide and with water. After drying over sodium sulfate, the chloroform is removed to give ethyl α-phthalimidopentanoate.

後処理

  1. customThe phases are separated
  2. extractionthe aqueous phase is extracted with chloroform
  3. extractionextracted with 0.1 N sodium hydroxide and with water
  4. dry with materialAfter drying over sodium sulfate
  5. customthe chloroform is removed

出典と根拠

ORDレコード
ord-238e2c7868bf4c0ab667f4ccfcc35579
出典データセット
uspto-grants-1979_04
特許番号
US04148998

関連ノート

読み込み中…