Oxetane → 3-[N'-(3-Hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide

HRID 263167

反応式

HRID 263167 の反応式
[O:1]1[CH2:4][CH2:3][CH2:2]1.[Br-:5].[CH3:6][N+:7]([CH3:14])([CH3:13])[CH2:8][CH2:9][CH2:10][NH:11][CH3:12]>O>[Br-:5].[OH:1][CH2:2][CH2:3][CH2:4][N:11]([CH2:10][CH2:9][CH2:8][N+:7]([CH3:14])([CH3:13])[CH3:6])[CH3:12]

参加物

4

反応物 2

HCID 10423OxetaneHCID 21444211N,N,N-Trimethyl-3-(methylamino)propan-1-aminium bromide

生成物 1

HCID 233475683-[N'-(3-Hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 20 g. of oxetane (0.34 mole), 32.8 g. of N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide (0.156 mole) and 22 ml. water is heated in a sealed tube at 100° for 15 hours. The solution is evaporated in vacuo and the residue is dissolved in 50 ml. of acetonitrile and filtered. Upon evaporation the desired product crystallizes. The product may be recrystallized from acetonitrile.

後処理

  1. additionA mixture of 20 g
  2. customThe solution is evaporated in vacuo
  3. dissolutionthe residue is dissolved in 50 ml
  4. filtrationof acetonitrile and filtered
  5. customUpon evaporation the desired product
  6. customcrystallizes
  7. customThe product may be recrystallized from acetonitrile

出典と根拠

ORDレコード
ord-f2c120316ee347cb8ea232a7c1248f59
出典データセット
uspto-grants-1979_05
特許番号
US04156693

関連ノート

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