Oxetane → 3-[N'-(3-Hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide
反応式
[O:1]1[CH2:4][CH2:3][CH2:2]1.[Br-:5].[CH3:6][N+:7]([CH3:14])([CH3:13])[CH2:8][CH2:9][CH2:10][NH:11][CH3:12]>O>[Br-:5].[OH:1][CH2:2][CH2:3][CH2:4][N:11]([CH2:10][CH2:9][CH2:8][N+:7]([CH3:14])([CH3:13])[CH3:6])[CH3:12]参加物
4
実験手順
A mixture of 20 g. of oxetane (0.34 mole), 32.8 g. of N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide (0.156 mole) and 22 ml. water is heated in a sealed tube at 100° for 15 hours. The solution is evaporated in vacuo and the residue is dissolved in 50 ml. of acetonitrile and filtered. Upon evaporation the desired product crystallizes. The product may be recrystallized from acetonitrile.
後処理
- additionA mixture of 20 g
- customThe solution is evaporated in vacuo
- dissolutionthe residue is dissolved in 50 ml
- filtrationof acetonitrile and filtered
- customUpon evaporation the desired product
- customcrystallizes
- customThe product may be recrystallized from acetonitrile
出典と根拠
- ORDレコード
- ord-f2c120316ee347cb8ea232a7c1248f59
- 出典データセット
- uspto-grants-1979_05
- 特許番号
- US04156693
反応ノート
読み込み中…