反応式
[N:1]1([CH2:6][CH2:7][CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:4][CH:3]=[CH:2]1.C(N(CC)CC)C.C(OC(Cl)=O)C(C)C.[C:27]([O:30][CH2:31][C:32]1[CH2:39][S:38][CH:37]2[N:34]([C:35](=[O:41])[CH:36]2[NH2:40])[C:33]=1[C:42]([OH:44])=[O:43])(=[O:29])[CH3:28]>O1CCCC1.O>[C:27]([O:30][CH2:31][C:32]1[CH2:39][S:38][CH:37]2[N:34]([C:35](=[O:41])[CH:36]2[NH:40][C:9](=[O:11])[CH2:8][CH2:7][CH2:6][N:1]2[CH:2]=[CH:3][CH:4]=[CH:5]2)[C:33]=1[C:42]([OH:44])=[O:43])(=[O:29])[CH3:28]参加物
反応物 4
生成物 1
試薬・触媒・溶媒 2
反応条件
- 温度
- -10 °C
実験手順
4-(1-Pyrryl)butanoic acid (0.05 mole) is dissolved in 50 ml of tetrahydrofuran (THF) and 0.05 mole of triethylamine is added. This mixture is cooled to -10° C. and 0.05 mole of isobutylchloroformate is added. The mixture is stirred for 0.5 hours at -5° C. and then 0.05 mole of 3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid and 0.075 mole of triethyl amine in 50 ml of THF (precooled) is added. The mixture is stirred at 0° C. for 1 hour and then warmed to room temperature. The mixture is diluted with water and extracted with ethyl acetate. The aqueous layer is acidified and extracted with ethyl acetate. The ethyl acetate extracts are combined, dried, filtered, and the solvent evaporated to give the title compound.
後処理
- stirringThe mixture is stirred at 0° C. for 1 hour
- temperaturewarmed to room temperature
- extractionextracted with ethyl acetate
- extractionextracted with ethyl acetate
- customdried
- filtrationfiltered
- customthe solvent evaporated
出典と根拠
- ORDレコード
- ord-6631c8a00d354e8eb16797c3c5063d19
- 出典データセット
- uspto-grants-1979_04
- 特許番号
- US04148998
関連ノート
読み込み中…