Nitric Acid → 8-Chloro-2-methyl-5-nitroquinoline

HRID 26363

反応式

HRID 26363 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[N+:13]([O-])([OH:15])=[O:14].[OH-].[Na+]>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:13]([O-:15])=[O:14])=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2

参加物

5

反応物 3

HCID 944Nitric AcidHCID 14798Sodium HydroxideHCID 2211138-Chloro-2-methylquinoline

生成物 1

HCID 177506238-Chloro-2-methyl-5-nitroquinoline収率 96.7%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

53.3 g (0.3 mole) of the resulting 8-chloroquinaldine was dissolved in 180.2 g of 98% sulfuric acid, and at 40° C., 40.2 g of nitric acid (specific gravity 1.50) was added dropwise over the course of 1 hour, followed by further reaction for 30 minutes. The reaction mixture was poured into ice water, and neutralized with an aqueous solution of sodium hydroxide. The product precipitated was collected by filtration, washed with water, and dried to afford 64.1 g (0.29 mole) of 8-chloro-5-nitroquinaldine.

後処理

  1. customfollowed by further reaction for 30 minutes
  2. customThe product precipitated
  3. filtrationwas collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-20462d786d2d4e94adfd61fbc12d4b76
出典データセット
uspto-grants-1979_04
特許番号
US04150025

関連ノート

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