Nitric Acid → 4-Acetamido-3-nitrobenzophenone

HRID 26377ノート

反応式

HRID 26377 の反応式
[C:1](OC(=O)C)(=O)C.[N+:8]([O-:11])(O)=[O:9].[NH2:12][C:13](N)=[O:14].[C:16]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(O)(=O)C>[C:13]([NH:12][C:20]1[CH:21]=[CH:22][C:17]([C:16]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:23])=[CH:18][C:19]=1[N+:8]([O-:11])=[O:9])(=[O:14])[CH3:1]

参加物

6

反応物 4

HCID 944Nitric AcidHCID 1176UreaHCID 3102BenzophenoneHCID 7918Acetic Anhydride

生成物 1

HCID 5969694-Acetamido-3-nitrobenzophenone収率 62.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

反応条件

温度
50 °C

実験手順

Twenty-three grams (0.1 m.) of 4-acetamidonbenzophenone, 50 ml. of acetic anhydride and 20 ml. of acetic acid were stirred together. A solution of 90 percent nitric acid (15 ml.), 10 ml. of acetic acid and 0.2 g. of urea was added dropwise to the benzophenone mixture. The reaction mixture was maintained at a temperature of about 50° C. during the nitration. The mixture was stirred at ambient temperature whereupon the mixture became very thick. The thick slurry was poured over ice and the insoluble product was filtered to yield 17.7 g. (62.5 percent yield) of 4-acetamido-3-nitrobenzophenone.

後処理

  1. additionThe thick slurry was poured over ice
  2. filtrationthe insoluble product was filtered
  3. customto yield 17.7 g

出典と根拠

ORDレコード
ord-20ce1551141f46029f3fc8dbcb037de1
出典データセット
uspto-grants-1979_04
特許番号
US04150028

反応ノート

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