Bromoacetonitrile → (R)-2-Amino-3-((cyanomethyl)thio)propanoic acid
反応式
O.Cl.[NH2:3][C@H:4]([C:7]([OH:9])=[O:8])[CH2:5][SH:6].[OH-].[Na+].Br[CH2:13][C:14]#[N:15]>O1CCOCC1>[C:14]([CH2:13][S:6][CH2:5][C@@H:4]([C:7]([OH:9])=[O:8])[NH2:3])#[N:15]参加物
5
実験手順
A 360 mL aqueous solution of commercially available (Aldrich) L-cysteine hydrochloride monohydrate (60.0 g, 341.7 mmole) and sodium hydroxide (27.33 g, 683.4 mmole), at room temperature, is treated with a solution of bromoacetonitrile (44.5 g, 370.6 mmole) in 130 mL of dioxane over 30 minutes. The reaction is stirred for 18 hours, during which time a thick precipitate will form. The solid is filtered off, washed with diethyl ether (100 mL) and dried under high vacuum at 40° C. to give the title compound.
後処理
- customwill form
- filtrationThe solid is filtered off
- washwashed with diethyl ether (100 mL)
- customdried under high vacuum at 40° C.
出典と根拠
- ORDレコード
- ord-449181e19a584136877ea9844e134996
- 出典データセット
- uspto-grants-1997_07
- 特許番号
- US05646165
反応ノート
読み込み中…