1,3-Dibromopropane → N,N-dimethyl4 bromopropoxy-3-methoxybenzamide

反応式

[CH3:1][N:2]([CH3:14])[C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([O:11][CH3:12])[CH:5]=1.C(=O)([O-])[O-].[K+].[K+].[Br:21][CH2:22][CH2:23][CH2:24]Br>C(#N)C>[CH3:14][N:2]([CH3:1])[C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:24][CH2:23][CH2:22][Br:21])=[C:6]([O:11][CH3:12])[CH:5]=1

参加物

実験手順

To N,N-dimethyl-4-hydroxy-3-methoxybenzamide (5.64 g, 28.7 mmol) in acetonitrile (450 ml) was added potassium carbonate (7.9 g) followed by 1,3-dibromopropane (11.6 g). The resulting reaction mixture was refluxed for 3 hours and stirred at room temperature for 12 hours. The mixture was filtered and concentrated to an oil. Following purification by column chromatography, N,N-dimethyl-4-bromopropoxy-3-methoxybenzamide as a colorless oil (7.6 g) was obtained.