Dihydroxyacetone → 2-(5-Bromo-2-methoxyphenyl)-4-hydroxymethylimidazole
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([NH2:9])=[NH:8].[OH:13][CH2:14][C:15]([CH2:17]O)=O.[Cl-].[NH4+].[OH-].[NH4+]>O1CCCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([C:7]2[NH:9][C:15]([CH2:14][OH:13])=[CH:17][N:8]=2)[CH:10]=1参加物
6
反応条件
- 温度
- 90 °C
実験手順
A mixture of 5-Bromo-2-methoxy-benzamidine (1.5 g), 1,3-dihydroxy-acetone dimer (1.0 g), ammonium chloride (1.3 g), tetrahydrofuran (3 mL) and concentrated aqueous ammonium hydroxide (10 mL) was heated at 90° C. for 3 h. The reaction mixture was chilled on ice and the precipitated product was collected and recrystallized from methanol to afford 2-(5-Bromo-2-methoxyphenyl)-5-hydroxymethyl-imidazole as a yellow solid.
後処理
- temperatureThe reaction mixture was chilled on ice
- customthe precipitated product was collected
- customrecrystallized from methanol
出典と根拠
- ORDレコード
- ord-1723b098082c46e9985a8431c1d72bea
- 出典データセット
- uspto-grants-1997_07
- 特許番号
- US05646279
反応ノート
読み込み中…