Methyl Isocyanate → N-(3-methyl-5-isothiazolyl)-N'-methylurea

HRID 26576

反応式

HRID 26576 の反応式
[CH3:1][N:2]=[C:3]=[O:4].[NH2:5][C:6]1[S:10][N:9]=[C:8]([CH3:11])[CH:7]=1>O1CCCC1>[CH3:11][C:8]1[CH:7]=[C:6]([NH:5][C:3]([NH:2][CH3:1])=[O:4])[S:10][N:9]=1

参加物

4

反応物 2

HCID 12228Methyl IsocyanateHCID 323073-Methylisothiazol-5-amine

生成物 1

HCID 23336007N-(3-methyl-5-isothiazolyl)-N'-methylurea収率 54.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Methylisocyanate (1.96 milliliters, 0.04 mole) was added dropwise to a thirty (30) milliliter solution of tetrahydrofuran (distilled from calcium hydride) containing the above mentioned 5-amino-3-methylisothiazole (5.0 grams, 0.04 mole), and then the resulting yellow solution was refluxed for 3 hours, during which time a white precipitate formed. The solution was cooled and filtered, giving 3.73 grams of 1-(3-methyl-5-isothiazolyl)-3-methylurea, also referred to as 3-methyl-5-N-methylureidoisothiazole.

後処理

  1. additioncontaining the
  2. temperaturethe resulting yellow solution was refluxed for 3 hours, during which time a white precipitate
  3. customformed
  4. temperatureThe solution was cooled
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-4dabd8acaf6f44008abf1131372dba24
出典データセット
uspto-grants-1979_04
特許番号
US04150226

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