Sodium Hydroxide → 4-(4-Chlorobutyloxy)benzoic acid

HRID 265892ノート

反応式

HRID 265892 の反応式
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=[O:12])=[CH:9][CH:8]=1.[OH-].[Na+].OS([O-])(=O)=O.[K+]>C(O)C>[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([C:11]([OH:13])=[O:12])=[CH:15][CH:16]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 516920Potassium bisulfateHCID 14575308Methyl 4-(4-chlorobutoxy)benzoate

生成物 1

HCID 190341754-(4-Chlorobutyloxy)benzoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

A mixture of 24-2 (3.0 g, 12.4 mmol), 1N NaOH (30 mL), and ethanol was heated at 60° C. for 1.0 hour. The cooled reaction mixture was acidified with 10% KHSO4 and then extracted with EtOAc. The EtOAc portion was washed with brine, dried (MgSO4) and concentrated to give 24-3 as a white solid.

後処理

  1. customThe cooled reaction mixture
  2. extractionextracted with EtOAc
  3. washThe EtOAc portion was washed with brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-21803ed5b24647c39e159b4ca30aa559
出典データセット
uspto-grants-1997_07
特許番号
US05648368

反応ノート

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