Acetonitrile → 2-Methylquinazoline
反応式
[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4](C1C=CC=CC=1)=O.[C:16](#[N:18])[CH3:17]>>[CH3:17][C:16]1[N:18]=[CH:4][C:3]2[C:2](=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:1]=1参加物
3
実験手順
In this method, the 2-aminobenzophenone derivative (IV) is reacted with acetonitrile to give the 2-methylquinazoline derivative (IX). The compound (IX) is subjected to bromination to give the 2-bromomethylquinazoline derivative (II-4). The reaction of the compound (IV) with acetonitrile can be carried out according to the same manner as that of Method D. The bromination of the compound (IX) can be carried out according to the same manner as that of the bromination of the compound (VII) in Method C.
出典と根拠
- ORDレコード
- ord-c9dd40a373ab4a39b3ccca2a27630ca6
- 出典データセット
- uspto-grants-1997_07
- 特許番号
- US05650410
反応ノート
読み込み中…