p-Toluenesulfonic acid → 115661-42-2

HRID 266697ノート

反応式

HRID 266697 の反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:15][C:16]1[CH:17]=[C:18]([CH:20]=[CH:21][C:22]=1[Cl:23])[NH2:19].CC1C=CC(S(O)(=O)=O)=CC=1.[BH4-].[Na+]>C1(C)C=CC=CC=1>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:19][C:18]2[CH:20]=[CH:21][C:22]([Cl:23])=[C:16]([Cl:15])[CH:17]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 6101p-Toluenesulfonic acidHCID 72573,4-DichloroanilineHCID 192201-Benzyl-4-piperidoneHCID 4311764Sodium borohydride

生成物 1

HCID 10854237115661-42-2

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

190 mmol of 1-benzyl-4-piperidone, 240 mmol of 3,4-dichloroaniline, 0.02 g of PTSA and 200 ml of toluene are placed in a round-bottomed flask equipped with a reflux condenser and a Dean and Stark apparatus. The whole mixture is brought to reflux for 24 hours. After evaporation of the solvent, the residue is taken up in 500 ml of methanol and 450 mmol of sodium borohydride are progressively added. The whole mixture is kept stirring for two days. The expected product is obtained after concentration by filtration of the precipitate formed.

後処理

  1. customequipped with a reflux condenser
  2. temperatureto reflux for 24 hours
  3. customAfter evaporation of the solvent

出典と根拠

ORDレコード
ord-3929200658124e9a870abb2589dd35f0
出典データセット
uspto-grants-1997_07
特許番号
US05652246

反応ノート

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