Chloroacetyl chloride → 4-Chloroacetamido-3-hydroxypyridine

HRID 266915

反応式

HRID 266915 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[OH:8].[Cl:9][CH2:10][C:11](Cl)=[O:12]>>[Cl:9][CH2:10][C:11]([NH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[OH:8])=[O:12]

参加物

3

反応物 2

HCID 6577Chloroacetyl chlorideHCID 27624194-Amino-3-hydroxypyridine

生成物 1

HCID 190316634-Chloroacetamido-3-hydroxypyridine

実験手順

A solution of 4-amino-3-hydroxypyridine (7 g, 0.06 mol) and chloroacetyl chloride (50 ml) was refluxed for 2 hours, cooled and the excess solvent was removed by vacuum distillation. The crude material was dissolved in water, neutralized with Na2CO3 and the solid precipitated filtered and air dried to give the desired product, m.p. 155°-158° C. The structural assignment was supported by the proton NMR spectrum.

後処理

  1. temperaturecooled
  2. customthe excess solvent was removed by vacuum distillation
  3. dissolutionThe crude material was dissolved in water
  4. customthe solid precipitated
  5. filtrationfiltered
  6. customair dried

出典と根拠

ORDレコード
ord-0e717692545847bf99de662dd998060e
出典データセット
uspto-grants-1997_07
特許番号
US05652363

関連ノート

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