Benzyl chloroformate → Z-L-2-Nal-OH

HRID 267150

反応式

HRID 267150 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][C@@H:12]([C:14]([OH:16])=[O:15])[NH2:13].[OH-].[Na+].Cl[C:20]([O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:21]>O>[CH2:23]([O:22][C:20]([NH:13][C@H:12]([C:14]([OH:16])=[O:15])[CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)=[O:21])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

参加物

5

反応物 3

HCID 10387Benzyl chloroformateHCID 14798Sodium Hydroxide2 回HCID 1859152-Naphthylalanine

生成物 1

HCID 7023496Z-L-2-Nal-OH

試薬・触媒・溶媒 1

HCID 962Water溶媒3 回

実験手順

5 g of 3-(2-naphthyl)-L-alanine and 0.93 g of sodium hydroxide in 12 ml of water were cooled to 0° C. and stirred while a solution of 1.4 g of sodium hydroxide in 9 ml of water and 5 ml of benzyl chloroformate were added simultaneously during 10 minutes. Stirring was continued for 2 hours and the mixture was allowed to come to room temperature. The mixture was diluted with water and then extracted with diethyl ether. The aqueous layer was acidified with 4 ml of concentrated hydrochloric acid and extracted with ethyl acetate. The ethyl acetate extracts were back-washed with water. The combined ethyl acetate extracts were dried over sodium sulphate, filtered, evaporated and triturated with petroleum ether (boiling point 40°-60° C.) to give 7.5 g of N-(benzyloxycarbonyl)-3-(2-naphthyl)-L-alanine of melting point 109°-111° C.

後処理

  1. additionwere added simultaneously during 10 minutes
  2. customto come to room temperature
  3. extractionextracted with diethyl ether
  4. extractionextracted with ethyl acetate
  5. washThe ethyl acetate extracts were back-washed with water
  6. dry with materialThe combined ethyl acetate extracts were dried over sodium sulphate
  7. filtrationfiltered
  8. customevaporated
  9. customtriturated with petroleum ether (boiling point 40°-60° C.)

出典と根拠

ORDレコード
ord-a64ce1488bfe4cde846f6a628aabe9e0
出典データセット
uspto-grants-1997_07
特許番号
US05652369

関連ノート

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