N-Bromoacetamide → Sodium (2-hydroxy-1-bromopropyl)-phosphonate

HRID 267564

反応式

HRID 267564 の反応式
[CH:1](/[P:4](=[O:7])([OH:6])[OH:5])=[CH:2]/[CH3:3].[OH-:8].[Na+:9].[Br:10]NC(=O)C>O>[OH:8][CH:2]([CH3:3])[CH:1]([P:4](=[O:6])([O-:5])[O-:7])[Br:10].[Na+:9].[Na+:9]

参加物

5

反応物 3

HCID 4353N-Bromoacetamide2 回HCID 14798Sodium HydroxideHCID 6436667P-(1Z)-1-Propen-1-ylphosphonic acid

生成物 1

HCID 86733120Sodium (2-hydroxy-1-bromopropyl)-phosphonate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

10.8 g. of cis-propenylphosphonic acid is dissolved in 50 ml. of water and the pH of the solution is adjusted to 4.2 by the addition of 2.5 N sodium hydroxide. 13.8 g. of N-bromoacetamide is added and the suspension is stirred at room temperature. The reaction is complete when the N-bromoacetamide is in solution and the mixture is negative to starch-iodide paper. The solution is lyophilized and the residue is triturated several times with chloroform to give sodium (2-hydroxy-1-bromopropyl)-phosphonate.

後処理

  1. customthe residue is triturated several times with chloroform

出典と根拠

ORDレコード
ord-d3df9ff839424b4a863354e31b5ebf93
出典データセット
uspto-grants-1976_03
特許番号
US03943153

関連ノート

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