Water → N-(1-Chlorobutan-2-yl)acetamide

HRID 267839

反応式

HRID 267839 の反応式
[C:1](#[N:3])[CH3:2].[OH2:4].C([O-])([O-])=O.[Na+].[Na+].[CH2:11]=[CH:12][CH2:13][CH3:14].[Cl:15]Cl>>[Cl:15][CH2:11][CH:12]([NH:3][C:1](=[O:4])[CH3:2])[CH2:13][CH3:14]

参加物

6

反応物 5

HCID 962WaterHCID 6342AcetonitrileHCID 78441-ButeneHCID 10340Sodium CarbonateHCID 24526Chlorine

生成物 1

HCID 12803237N-(1-Chlorobutan-2-yl)acetamide収率 44%

反応条件

温度
25 °C

実験手順

A 500 ml. 3-necked flask fitted with a stirrer and dry ice-acetone trap is charged with 82.1 g. (2.0 mole) acetonitrile, 27.4 g. (1.52 mole) water, 27 g. (0.25 mole) Na2CO3 and 28.1 g. (0.50 mole) 1-butene and cooled to 0° C. Chlorine (0.50 mole) is added over 1/2 hour, the reaction temperature reaching a high of 32° C. After stirring for 2 hours at 25° C., the reaction mixture is filtered. The acetonitrile washings of the solid phase and filtrate is combined and the solvents removed by vacuum distillation to leave 33.0 g. of the N-[1-(chloromethyl)propyl]acetamide (44.0 percent yield based on 1-butene).

後処理

  1. custom3-necked flask fitted with a stirrer and dry ice-acetone trap
  2. additionis charged with 82.1 g
  3. customhigh of 32° C
  4. filtrationthe reaction mixture is filtered
  5. customthe solvents removed by vacuum distillation
  6. customto leave 33.0 g

出典と根拠

ORDレコード
ord-add3ef3a8fb042f2b1cb6c2bf3d1e80b
出典データセット
uspto-grants-1976_03
特許番号
US03944608

関連ノート

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