Cysteamine Hydrochloride → 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride
反応式
[ClH:1].O[CH2:3][C:4]1[N:5]=[CH:6][NH:7][C:8]=1[CH3:9].Cl.[NH2:11][CH2:12][CH2:13][SH:14]>C(O)(=O)C>[ClH:1].[ClH:1].[CH3:9][C:8]1[N:7]=[CH:6][NH:5][C:4]=1[CH2:3][S:14][CH2:13][CH2:12][NH2:11]参加物
4
実験手順
(i)(a) A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30.0 g.) and cysteamine hydrochloride (23.0 g.) in acetic acid (200 ml.) was heated under reflux for 10 hours. Following cooling to 15°-20°, the solid which crystallised was collected and washed with isopropyl alcohol to give 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride (45.5 g.), m.p. 189°-192°.
後処理
- temperatureunder reflux for 10 hours
- temperatureFollowing cooling to 15°-20°
- customthe solid which crystallised
- customwas collected
- washwashed with isopropyl alcohol
出典と根拠
- ORDレコード
- ord-6ef02c204531486b9758f3aef7927054
- 出典データセット
- uspto-grants-1979_04
- 特許番号
- US04151288
反応ノート
読み込み中…