Hydroxylamine → HCID 10086467、化合物

HRID 268207ノート

反応式

HRID 268207 の反応式
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([CH2:9][C:10]2[CH:15]=[C:14]([O:16][CH3:17])[C:13]([O:18][CH3:19])=[C:12]([O:20][CH3:21])[CH:11]=2)=[CH:4][N:3]=1.[NH2:22][OH:23].Cl.NO.[Na]>CO>[NH2:1][C:2]1[N:7]=[C:6]([NH:22][OH:23])[C:5]([CH2:9][C:10]2[CH:15]=[C:14]([O:16][CH3:17])[C:13]([O:18][CH3:19])=[C:12]([O:20][CH3:21])[CH:11]=2)=[CH:4][N:3]=1

参加物

6

反応物 4

HCID 787HydroxylamineHCID 443297Hydroxyamine hydrochlorideHCID 5360545SodiumHCID 2028496555694-04-7

生成物 1

HCID 10086467HCID 10086467、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3 g of 2-amino-4-chloro-5-(3,4,5-trimethoxybenzyl)-pyrimidine is added to a methanolic hydroxylamine solution prepared from 1.4 g of hydroxylamine-hydrochloride, 0.46 g of sodium and 50 ml of absolute methanol. The mixture is stirred for 48 hours at 40°; it is subsequently concentrated in vacuo and the residue is recrystallised from butanol to obtain 2-amino-4-(hydroxyamino)-5-(3,4,5-trimethoxybenzyl)-pyrimidine, M.P. 208°-210°, which is identical to the product described in Example 2.

後処理

  1. concentrationit is subsequently concentrated in vacuo
  2. customthe residue is recrystallised from butanol

出典と根拠

ORDレコード
ord-20a760ca266344d3836b3ee248a0be4b
出典データセット
uspto-grants-1976_03
特許番号
US03947441

反応ノート

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