Diboron → (3-Chloro-5-methylpyrazin-2-yl)methanol

HRID 26845

反応式

HRID 26845 の反応式
[Cl:1][C:2]1[C:3]([C:9](O)=[O:10])=[N:4][CH:5]=[C:6]([CH3:8])[N:7]=1.B#B>>[Cl:1][C:2]1[C:3]([CH2:9][OH:10])=[N:4][CH:5]=[C:6]([CH3:8])[N:7]=1

参加物

3

反応物 2

HCID 6328200DiboronHCID 205579983-Chloro-5-methylpyrazine-2-carboxylic acid

生成物 1

HCID 20557611(3-Chloro-5-methylpyrazin-2-yl)methanol

実験手順

Reduction of 3-chloro-5-methyl-2-pyrazinecarboxylic acid (prepared by alkaline hydrolysis of the methyl ester) with diborane gives 3-chloro-2-hydroxymethyl-5-methylpyrazine which, using the above procedure, yields N-methyl-N'-[2-((3-chloro-5-methyl-2-pyrazinyl)methylthio)ethyl]thiourea.

出典と根拠

ORDレコード
ord-324645d3203042189d7320a49ef1caf8
出典データセット
uspto-grants-1979_04
特許番号
US04151288

関連ノート

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