Purine → Nebularine

HRID 268513

反応式

HRID 268513 の反応式
[N:1]1[CH:9]=[C:8]2[C:4]([N:5]=[CH:6][NH:7]2)=[N:3][CH:2]=1.Cl[C@:11]1(CO)[O:16][C:14]([C:17](=[O:19])C)(O)[C@:13](C(=O)C)([OH:20])[C@:12]1(C(=O)C)[OH:24].CO.N>C(Cl)(Cl)Cl>[CH:9]1[C:8]2[N:7]=[CH:6][N:5]([C@@H:11]3[O:16][C@H:14]([CH2:17][OH:19])[C@@H:13]([OH:20])[C@H:12]3[OH:24])[C:4]=2[N:3]=[CH:2][N:1]=1

参加物

5

反応物 3

HCID 1044Purine2 回HCID 21705897Ammonia methanolHCID 131710119Chlorotriacetylribofuranose

生成物 1

HCID 68368Nebularine

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Nebularine was prepared by the use of the thallous salt of purine in the procedure of Brown et al., J. Biol. Chem. 204, 1019 (1953), in place of the chloromercuri salt used therein. The thallous salt of purine is condensed with chlorotriacetylribofuranose and the resulting acetyl derivative hydrolyzed to the product with methanol-ammonia. Other experimental conditions were identical. Crystalline nebularine was obtained after chromatography of the crude product on silica-gel with chloroform.

出典と根拠

ORDレコード
ord-b9a10572cee545b7be20058119fe82e0
出典データセット
uspto-grants-1976_03
特許番号
US03947488

関連ノート

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