Methyl iodide → Metribuzin

HRID 26951

反応式

HRID 26951 の反応式
[SH:1][C:2]1[N:7]([NH2:8])[C:6](=[O:9])[C:5]([C:10]([CH3:13])([CH3:12])[CH3:11])=[N:4][N:3]=1.[CH3:14]I>[OH-].[Na+].CO>[CH3:14][S:1][C:2]1[N:7]([NH2:8])[C:6](=[O:9])[C:5]([C:10]([CH3:13])([CH3:12])[CH3:11])=[N:4][N:3]=1

参加物

5

反応物 2

HCID 6328Methyl iodideHCID 178441961HCID 178441961、化合物

生成物 1

HCID 30479Metribuzin収率 82%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 14798Sodium Hydroxide溶媒

反応条件

温度
20 °C

実験手順

4 parts by weight of 3-mercapto-4-amino-6-tert.-butyl-1,2,4-triazin-5-(4H)-one are dissolved in a mixture of 11 parts by weight of 2 normal sodium hydroxide solution and 4 parts by weight of methanol and the solution is treated at 0° C. with 3.2 parts by weight of methyl iodide. The reaction mixture is then stirred at 20° C. for a further 4 hours. The reaction product crystallizes out, is filtered off, dried and recrystallized from benzene. 3.52 parts by weight of 3-methylthio-4-amino-6-tert.-butyl-1,2,4-triazin-5(4H)-one (XV) of melting point 126°-127° are obtained. Yield: 82% of theory.

後処理

  1. customThe reaction product crystallizes out
  2. filtrationis filtered off
  3. customdried
  4. customrecrystallized from benzene

出典と根拠

ORDレコード
ord-895559a8b91f4e94b2870734f5b36b91
出典データセット
uspto-grants-1979_04
特許番号
US04151355

関連ノート

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