Sodium hydride → Ethyl 3-bromo-5-(2-oxo-1-pyrrolidinyl)benzoate

HRID 269561ノート

反応式

HRID 269561 の反応式
[H-].[Na+].[Br:3][C:4]1[CH:5]=[C:6]([CH:12]=[C:13]([NH:15][C:16](=[O:21])[CH2:17][CH2:18][CH2:19]Cl)[CH:14]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8]>C1COCC1>[Br:3][C:4]1[CH:5]=[C:6]([CH:12]=[C:13]([N:15]2[CH2:19][CH2:18][CH2:17][C:16]2=[O:21])[CH:14]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8]

参加物

4

反応物 2

HCID 24758Sodium hydrideHCID 69312186Ethyl 3-bromo-5-[(4-chlorobutanoyl)amino]benzoate

生成物 1

HCID 69310922Ethyl 3-bromo-5-(2-oxo-1-pyrrolidinyl)benzoate収率 82%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Sodium hydride, 60% suspension in oil (186 mg, 4.65 mmol) was added portionwise over 2 mins to a solution of ethyl 3-bromo-5-[(4-chlorobutanoyl)amino]benzoate (1.35 g, 3.87 mmol) in dry THF (50 ml) under nitrogen. The reaction mixture was stirred at room temperature for 2 hours. The reaction was quenched by the careful addition of water (25 ml). Diethyl ether (50 ml) was added. The organic phase was washed with water, dried and evaporated to give the title compound as a yellow solid (990 mg, 82%).

後処理

  1. customThe reaction was quenched by the careful addition of water (25 ml)
  2. additionDiethyl ether (50 ml) was added
  3. washThe organic phase was washed with water
  4. customdried
  5. customevaporated

出典と根拠

ORDレコード
ord-9e48a4e796894b0e8085b0dec450e126
出典データセット
uspto-grants-2008_11
特許番号
US07446222B2

反応ノート

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