Acetic Anhydride → N-(4-fluoro-2-hydroxyphenyl)acetamide

HRID 270055

反応式

HRID 270055 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-])=O)=[C:6]([OH:8])[CH:7]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>[Pt].CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:9][C:12](=[O:14])[CH3:13])=[C:6]([OH:8])[CH:7]=1

参加物

5

反応物 2

HCID 7918Acetic AnhydrideHCID 99375-Fluoro-2-nitrophenol

生成物 1

HCID 177738N-(4-fluoro-2-hydroxyphenyl)acetamide収率 87.4%

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 887Methanol溶媒

実験手順

A mixture of 5-fluoro-2-nitrophenol (5 g, 31.8 mmol), acetic anhydride (4.86 g, 47.7 mmol) and platinum on carbon (5%, 200 mg) in methanol was hydrogenated at 35 psi for 3 hours. The catalyst was filtered off and the residue was purified by silica gel flash chromatography to give the subtitled compound (4.7 g).

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe residue was purified by silica gel flash chromatography

出典と根拠

ORDレコード
ord-a26a1d68247b4745ab08f78a13da12b9
出典データセット
uspto-grants-2008_11
特許番号
US07449475B2

関連ノート

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