Trifluoroacetic acid → 4-Acetamido-3-hydroxyphenyl acetate

HRID 270087ノート

反応式

HRID 270087 の反応式
[C:1]([O:4][C:5]1[CH:14]=[CH:13][C:8]2[N:9]=[C:10]([CH3:12])[O:11][C:7]=2[CH:6]=1)(=[O:3])[CH3:2].FC(F)(F)C(O)=[O:18].C(=O)([O-])O.[Na+]>O1CCCC1>[C:1]([O:4][C:5]1[CH:14]=[CH:13][C:8]([NH:9][C:10](=[O:18])[CH3:12])=[C:7]([OH:11])[CH:6]=1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 156622632-Methylbenzo[d]oxazol-6-yl acetate

生成物 1

HCID 688181524-Acetamido-3-hydroxyphenyl acetate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

2-methyl-1,3-benzoxazol-6-yl acetate (8.1 g, 42.3 mmol) was dissolved in tetrahydrofuran (60 mL), and trifluoroacetic acid (4 mL, 53.2 mmol) was added. The light brown solution was stirred over night at room temperature. Sodium hydrogen carbonate (aq, sat) was added, and the solution was extracted twice with ethyl acetate. The combined organic layers were concentrated to the titled compound (8.0 g, 91%) as a beige solid.

後処理

  1. extractionthe solution was extracted twice with ethyl acetate
  2. concentrationThe combined organic layers were concentrated to the titled compound (8.0 g, 91%) as a beige solid

出典と根拠

ORDレコード
ord-d8dbe9912e804bef8afffdec1554dd7c
出典データセット
uspto-grants-2008_11
特許番号
US07449475B2

反応ノート

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