Trifluoroacetic acid → Morpholin-2-ylmethyl trifluoroacetate

HRID 270107

反応式

HRID 270107 の反応式
[OH:1][CH2:2][CH:3]1[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[C:16]([C:20](O)=[O:21])([F:19])([F:18])[F:17]>C(Cl)Cl>[F:17][C:16]([F:19])([F:18])[C:20]([O:1][CH2:2][CH:3]1[O:8][CH2:7][CH2:6][NH:5][CH2:4]1)=[O:21]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 5201202tert-Butyl 2-(hydroxymethyl)morpholine-4-carboxylate

生成物 1

HCID 11206644Morpholin-2-ylmethyl trifluoroacetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Tert-Butyl 2-(hydroxymethyl)-4-morpholinecarboxylate (5.13 g, 23.61 mmol) was treated with CF3CO2H (20 mL) in CH2Cl2 (50 mL) at room temperature for 3 h. The volatiles were removed in vacuo to give the subtitled compound (7.6 g).

後処理

  1. customThe volatiles were removed in vacuo

出典と根拠

ORDレコード
ord-cd13a1f2c918407faf5b11bd981b00ae
出典データセット
uspto-grants-2008_11
特許番号
US07449475B2

関連ノート

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