Formaldehyde → 6,7-dihydro-4H-thieno[3,2-c]pyran

HRID 270650

反応式

HRID 270650 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][OH:8].[CH2:9]=O>[Cl-].[In+3].[Cl-].[Cl-].C(#N)C>[S:1]1[C:2]2[CH2:6][CH2:7][O:8][CH2:9][C:3]=2[CH:4]=[CH:5]1

参加物

5

反応物 2

HCID 712FormaldehydeHCID 794002-Thiopheneethanol

生成物 1

HCID 114691186,7-dihydro-4H-thieno[3,2-c]pyran収率 66%

試薬・触媒・溶媒 2

HCID 159675indium(III)chloride触媒HCID 6342Acetonitrile溶媒

実験手順

20.0 g of 2-thiopheneethanol, 6.1 g of paraformaldehyde, and 1.7 g of indium(III) chloride were added to 1,500 mL of acetonitrile, and the resulting mixture was refluxed for 2 hours. The reaction solution was cooled to room temperature and concentrated by evaporation under reduced pressure. The residue thus obtained was distilled under reduced pressure to obtain 14.4 g (yield of 66%) of the title compound as an oil form.

後処理

  1. temperaturethe resulting mixture was refluxed for 2 hours
  2. concentrationconcentrated by evaporation under reduced pressure
  3. customThe residue thus obtained
  4. distillationwas distilled under reduced pressure

出典と根拠

ORDレコード
ord-f1af7314c9d74d34a0d585c7fbd68390
出典データセット
uspto-grants-2008_11
特許番号
US07449580B2

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