Formaldehyde → 6,7-dihydro-4H-thieno[3,2-c]pyran

HRID 270651

反応式

HRID 270651 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][OH:8].[CH2:9]=O.[In+3]>C(#N)C>[S:1]1[C:2]2[CH2:6][CH2:7][O:8][CH2:9][C:3]=2[CH:4]=[CH:5]1

参加物

5

反応物 3

HCID 712FormaldehydeHCID 794002-ThiopheneethanolHCID 105148Indium cation

生成物 1

HCID 114691186,7-dihydro-4H-thieno[3,2-c]pyran収率 43%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

10.0 g of 2-thiopheneethanol, 2.8 g of paraformaldehyde, and 2.2 g of indium(III) triplate were added to 780 mL of acetonitrile, and the resulting mixture was refluxed for 12 hours. The reaction product solution was cooled to room temperature and concentrated by evaporation under reduced pressure. The residue was distilled under reduced pressure to obtain 4.7 g (yield of 43%) of the title compound, of which analysis data were the same as obtained in Example 14.

後処理

  1. temperaturethe resulting mixture was refluxed for 12 hours
  2. concentrationconcentrated by evaporation under reduced pressure
  3. distillationThe residue was distilled under reduced pressure

出典と根拠

ORDレコード
ord-7e4a235f7bf04b8a8b320af81373770d
出典データセット
uspto-grants-2008_11
特許番号
US07449580B2

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