Azobisisobutyronitrile → 6-Bromo-2-(bromomethyl)quinoline
反応式
CC(N=NC(C#N)(C)C)(C#N)C.[Br:13]N1C(=O)CCC1=O.[Br:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[N:28]=[C:27]([CH3:32])[CH:26]=[CH:25]2>C(Cl)(Cl)(Cl)Cl>[Br:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[N:28]=[C:27]([CH2:32][Br:13])[CH:26]=[CH:25]2参加物
5
実験手順
148 mg (1.00 mmol) α,α-azoisobutyronitrile and 8.01 g (45.0 mmol) N-bromosuccinimide are added successively to a solution of 10.0 g (45.0 mmol) 6-bromo-2-methyl-quinoline in 60 mL carbon tetrachloride. The reaction mixture is refluxed for 8 h. It is filtered and the filtrate is washed twice with water. The organic phase is dried over MgSO4 and the solvent is eliminated i.vac. The purification is carried out by column chromatography on silica gel (PE/EtOAc 4:1).
後処理
- temperatureThe reaction mixture is refluxed for 8 h
- filtrationIt is filtered
- washthe filtrate is washed twice with water
- dry with materialThe organic phase is dried over MgSO4
- customThe purification
出典と根拠
- ORDレコード
- ord-db2786f5491b42db8a1a82a6a28f7cd1
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07452911B2
反応ノート
読み込み中…