Isopropylamine → 1,3,5-Triazin-2-amine, 4,6-dichloro-N-(1-methylethyl)-

HRID 27222

反応式

HRID 27222 の反応式
[N:1]1[C:8]([Cl:9])=[N:7][C:5](Cl)=[N:4][C:2]=1[Cl:3].[CH:10]([NH2:13])([CH3:12])[CH3:11].[OH-].[Na+]>C(OCC)(=O)C>[Cl:9][C:8]1[N:1]=[C:2]([Cl:3])[N:4]=[C:5]([NH:13][CH:10]([CH3:12])[CH3:11])[N:7]=1

参加物

5

反応物 3

HCID 6363IsopropylamineHCID 7954Cyanuric chlorideHCID 14798Sodium Hydroxide

生成物 1

HCID 194531,3,5-Triazin-2-amine, 4,6-dichloro-N-(1-methylethyl)-

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
-15 °C

実験手順

A suspension of 369 g of cyanuric chloride in 1000 ml of ethyl acetate is cooled to -15° C. With good stirring, 124 g of isopropylamine are first added dropwise at -20° C. to -10° C. in the course of 21/2 hours, followed by 267 g of a 30% aqueous solution of sodium hydroxide in the course of one hour. The reaction mixture is stirred for a further 11/2 hours at the same temperature, then the organic phase is separated, washed with two 100 ml portions of water and dried over sodium sulphate. The solvent is evaporated, to yield an oil from which the 2,4-dichloro-6-isopropylamino-s-triazine precipitates in crystalline form after stirring with petroleum ether at low temperature. Melting point: 46°-47° C.

後処理

  1. customthe organic phase is separated
  2. washwashed with two 100 ml portions of water
  3. dry with materialdried over sodium sulphate
  4. customThe solvent is evaporated

出典と根拠

ORDレコード
ord-32cef9d776e644fa9ed2f82788d54e0e
出典データセット
uspto-grants-1980_09
特許番号
US04220770

関連ノート

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